Book Title : Informed Consent in Predictive Genetic Testing

informed consent in predictive genetic testing

Release Date : 2015-06-15
ISBN Code : 9783319174167
Book Author : Jessica Minor
Book Publisher : Springer
Total Pages : 232

Book Summary :

This important book proposes revising the current informed consent protocol for predictive genetic testing to reflect the trend toward patient-centered medicine. Emphasizing the predictive aspect of testing, the author analyzes the state of informed consent procedure in terms of three components: comprehension of risk assessment, disclosure to select appropriate treatment, and voluntariness. The book's revised model revisits these cornerstones, restructuring the consent process to allow for expanded comprehension time, enhanced patient safety, greater patient involvement and autonomy, and reduced chance of coercion by family or others. A comparison of the current and revised versions and case studies showing the new model in real-world applications add extra usefulness to this resource. Included in the coverage: The science behind PGT. Understanding genetic risks and probability. The history of informed consent. Revised model of informed consent: comprehension, disclosure, voluntariness, patient safety. Applications of the model in DTC and pleiotropic genetic testing. Implementation of the revised model, and assessing its effectiveness. A milestone in the bioethics literature, Informed Consent in Predictive Genetic Testing will be of considerable interest to genetic counselors, medical and bioethicists, and public health professionals.

Book Title : Frameworks of Choice

frameworks of choice

Release Date : 2010
ISBN Code : 9789089641656
Book Author : Margaret Sleeboom-Faulkner
Book Publisher : Amsterdam University Press
Total Pages : 271

Book Summary :

Frameworks of Choice verkent de culturele en politieke aspecten van voorspellende en genetische tests. Het boek analyseert de sociale, culturele, en economische gevolgen voor het individu na een voorspellende of genetische screening. Margaret Sleeboom-Fau.

Book Title : Inherited Metabolic Epilepsies

inherited metabolic epilepsies

Release Date : 2012-10-04
ISBN Code : 9781617050565
Book Author : Phillip L. Pearl, MD
Book Publisher : Demos Medical Publishing
Total Pages : 312

Book Summary :

The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together leading authorities presenting state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies opens with a section on general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, neuroimaging, seizure patterns and EEG findings, new technologies, and the ketogenic diet in metabolic epilepsies. The next two sections are devoted to the cohort of specific small molecule disorders (aminoacidopathies, organic acidopathies, mitochondrial disorders, urea cycle disorders, neurotransmitter disorders, and glucose-related disorders) and large molecule disorders (lysomal storage disorders, peroxisomal diseases, glycosylation defects, and leukodystrophies) that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction when considering an inherited metabolic disorder as the explanation for a patient with epilepsy. Inherited Metabolic Epilepsies Key Features: Presents the latest scientific thinking and clinical wisdom for a poorly understood group of disorders that have devastating consequences if unrecognized or not promptly treated Expert authorship from both the genetic-metabolic and epilepsy communities provides state-of-the-art guidance for understanding and managing these disorders A readable text for clinicians highlighting the relation between metabolic errors and epilepsy Concludes with a practical algorithm for evaluating a patient with a possible metabolic epilepsy

Book Title : Hereditary Breast Cancer

hereditary breast cancer

Release Date : 2007-09-19
ISBN Code : 1420020366
Book Author : Claudine Isaacs
Book Publisher : CRC Press
Total Pages : 400

Book Summary :

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

Book Title : Genetics Testing in the New Millennium

genetics testing in the new millennium

Release Date : 2001-01
ISBN Code : 0756705487
Book Author : Constance A. Morella
Book Publisher : DIANE Publishing
Total Pages : 123

Book Summary :

Hearing held by the Subcommittee on Technology. Witnesses include: Raymond G. Kammer, Director, National Institute of Standards and Technology; Dr. Francis S. Collins, Director, National Human Genome Research Institute, National Institutes of Health; Dr. William F. Raub, Deputy Assistant Secretary of Science Policy, Department of Health and Human Services (HHS); and Dr. Michael Watson, Professor of Pediatrics and Genetics, Washington University School of Medicine, Co-Chair, NIH-DoE Task Force of Genetics Testing.

Book Title : Genetic Testing

genetic testing

Release Date : 2006-01-20
ISBN Code : 9780471748885
Book Author : Neil F. Sharpe
Book Publisher : John Wiley & Sons
Total Pages : 544

Book Summary :

A complete review of the issues with specific recommendations and guidelines. With over 1,000 tests commercially available, genetic testing is revolutionizing medicine. Health care professionals diagnosing and treating patients today must consider genetic factors, the risks and limitations of genetic testing, and the relevant law. Genetic Testing: Care, Consent, and Liability offers the only complete, practical treatment of the genetic, clinical, ethical, and legal issue surrounding genetic testing. The authors present protocols, policies, and models of care that are currently in use, and explain the legal framework for genetic testing and counseling that has developed in North America, particularly with regard to the law of medical malpractice. This essential book features an international roster of esteemed contributors including, Nancy P. Callanan, Bonnie S. LeRoy, Carole H. Browner, H. Mabel Preloran, Riyana Babul-Hirji, Cheryl Shuman, M.J. Esplen, Maren T. Scheuner, Dena S. Davis, JonBeckwith, Lisa Geller, Mark A. Hall, Andrew R. MacRae, David Chitayat, Roxanne Mykitiuk, Stephanie Turnham, Mireille Lacroix, Jinger G, Hoop, Edwin H, Cook, Jr., S. H. Dinwiddie, Elliot S. Gershon, C. Anthony Rupar, Lynn Holt, Bruce R. Korf, Anne Summers, S. Annie Adams, Daniel L. Van Dyke, Rhett P. Ketterling, Erik C. Thorland, Timothy Caulfield, Lorraine Sheremeta, Richard Gold, Jon F. Merz, David Castle, Peter J. Bridge, JS Parboosingh, Patricia T. Kelly, Julianne M. O'Daniel, Allyn McConkie-Rosell, Beatrice Godard, Bartha Maria Knoppers, David Weisbrot. The coverage also includes: * Genetic screening, including prenatal, neonatal, carrier, and susceptibility testing * Diagnosis, risk assessment, confidentiality, and clinical/legal issues related to follow-up * Interpreting test results and communicating them to patients * psychological considerations * Informed consent * Family history evaluations * Referral to medical geneticists and genetic counselors Genetic Testing Care, Consent, and Liability is a must-have resource for clinical geneticists, genetic counselors, specialists, family physicians, nurses, public health professionals, and medical students.

Book Title : The Limits of Consent

the limits of consent

Release Date : 2009-01-29
ISBN Code : 9780199231461
Book Author : Oonagh Corrigan
Book Publisher : Oxford University Press
Total Pages : 234

Book Summary :

Informed consent in medical research : a procedure stretched beyond breaking point? / Søren Holm and Søren Madsen -- Trust and exploitation in clinical research / Paul B. Miller and Charles Weijer -- Consent and private liability in clinical research / Paul B. Miller and Josephine Johnston -- The decision to decline to enroll in a clinical trial : a blind spot in the literature on decision-making for research participation / Clare Snowdon, Diana Elbourne, and Jo Garcia -- Beyond a rebarbative commitment to consent / Kathy Liddell -- The normative status of the requirement to gain an informed consent in clinical trials : comprehension, obligations, and empirical evidence / Angus Dawson.

Book Title : Abeloff s Clinical Oncology E Book

abeloff s clinical oncology e book

Release Date : 2013-09-12
ISBN Code : 9781455728817
Book Author : John E. Niederhuber
Book Publisher : Elsevier Health Sciences
Total Pages : 2224

Book Summary :

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Book Title : Ethical Dilemmas in Genetics and Genetic Counseling

ethical dilemmas in genetics and genetic counseling

Release Date : 2014-09-25
ISBN Code : 9780199944897
Book Author : Janice L. Berliner
Book Publisher : Oxford University Press, USA
Total Pages : 226

Book Summary :

By using a creative approach that focuses on a single extended family as a case example to illustrate each chapter's key point, the authors elucidate ethical issues arising in the genetics clinic and laboratory surrounding many timely issues.

Book Title : The Drama of DNA

the drama of dna

Release Date : 2014-03-14
ISBN Code : 9780199373154
Book Author : Karen H. Rothenberg JD, MPA
Book Publisher : Oxford University Press
Total Pages : 224

Book Summary :

Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside. This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.

Book Title : Questions thiques en m decine pr dictive

questions thiques en m decine pr dictive

Release Date : 2006
ISBN Code : 2742006273
Book Author : Armelle de Bouvet
Book Publisher : John Libbey Eurotext
Total Pages : 153

Book Summary :

Les pratiques de la médecine prédictive suscitent un grand nombre questions éthiques. Quels sont les enjeux et les conséquences de telles pratiques pour le patient ? Quelles sont les questions majeures que les professionnels des pratiques biomédicales doivent se poser ? À partir de quelques exemples issus des pratiques cliniques (diagnostic prénatal médecine fœtal, tests génétiques) et des pratiques de recherche (dépistage du prédiabète de type 1), les auteurs (cliniciens et éthiciens) soulèvent toute une série de questions éthiques concernant les enjeux et les conséquences des pratiques prédictives pour le patient, mais aussi pour le devenir de la médecine et de ses missions. Pour répondre à ces questions fondamentales qui intéresseront autant les chercheurs et universitaires que les cliniciens, les auteurs font part à la fois de leurs expériences respectives et de leurs réflexions, qui se situent au croisement des pratiques biomédicales et de l'éthique.

Book Title : Excessive Medical Spending

excessive medical spending

Release Date : 2007-01
ISBN Code : 9781846191688
Book Author : Norman J. Temple
Book Publisher : Radcliffe Publishing
Total Pages : 195

Book Summary :

This work contains a Foreword by Merrill Goozner, Author and Director, Integrity in Science, Center for Science and the Public Interest, Washington DC. This book exposes why healthcare costs have been rapidly increasing and includes a close examination of over-priced drugs. It contains a detailed explanation of how the drug industry takes billions of dollars from society each year and proposes radical new ideas to reign in excessive spending on medicine. Based on the latest research, its unique approach takes into account the pharmaceutical industry, healthcare policy and society to offer a wide ranging account. It is invaluable for all healthcare professionals, especially managers and doctors and nurses with budgetary responsibilities. It will also be useful for researchers, policy makers and shapers, pharmaceutical company executives and general readers with an interest in medical expenditure.

Book Title : Applied Genetics in Healthcare

applied genetics in healthcare

Release Date : 2005
ISBN Code : 1859962742
Book Author : Heather Skirton
Book Publisher : Garland Science
Total Pages : 274

Book Summary :

This book is based on practical experience working in genetic healthcare and counseling, both in the UK and USA. It provides a sound scientific basis for both students and practitioners in the field, supported by case studies.

Book Title : Genetic Counselling

genetic counselling

Release Date : 2006-12-05
ISBN Code : 9781134890576
Book Author : Angus Clarke
Book Publisher : Routledge
Total Pages : 280

Book Summary :

Contributions to this study are drawn both from health professionals engaged in genetic counselling and from observers and critics with backgrounds in law, philosophy, biology, and the social sciences. This diversity will enable health professonals to examine their activities with a fresh eye, and will help the observer-critic to understand the ethical problems that arise in genetic counselling practice, rather than in imaginary encounters. Most examinations of the ethical issues raised by genetics are concerned in a broad sense with the application of new technology to human reproduction. This volume focuses on genetic counselling and screening as such, providing valuable insights for the health professional, social scientist, philosopher, lawyer, and bioethicist.

Book Title : Hereditary Colorectal Cancer

hereditary colorectal cancer

Release Date : 2010-09-10
ISBN Code : 144196603X
Book Author : Miguel A. Rodriguez-Bigas
Book Publisher : Springer Science & Business Media
Total Pages : 630

Book Summary :

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Book Title : Promoting Safe and Effective Genetic Testing in the United States

promoting safe and effective genetic testing in the united states

Release Date : 1998
ISBN Code : 0801859522
Book Author : Task Force on Genetic Testing (U.S.)
Book Publisher :
Total Pages : 186

Book Summary :

The members of this task force describe general principles involved in genetic testing, including informed consent, testing of children, confidentiality, and discrimination. They describe methods and policies to ensure the safety and effectiveness of new genetic tests. They discuss how to ensure the quality of laboratories that perform genetic tests, show how health care professionals outside the field of genetics can better understand the uses of genetic testing, and offer a look at testing for rare inherited genetic disorders.

Book Title : Resolving Ethical Dilemmas

resolving ethical dilemmas

Release Date : 2012-01-03
ISBN Code : 9781451178753
Book Author : Bernard Lo
Book Publisher : Lippincott Williams & Wilkins
Total Pages : 360

Book Summary :

This timely Fourth Edition offers clinicians expert guidance in approaching a wide range of ethical dilemmas and developing an action plan. Most chapters include real-life sample cases that the author walks through, discussing the salient issues and how to approach them. This edition includes a new chapter on ethical issues in cross-cultural medicine and new material on conscientious objection by physicians in reproductive health and other areas. Other topics addressed include disclosure of errors to patients, gifts to physicians from drug companies, involuntary psychiatric treatment, genomic medicine, and ethical issues during public health emergencies such as pandemics. The updated discussion of organ transplantation includes increasing the donor pool and non-heart beating donors.